Meclofenamic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

甲氯芬那酸是一种非选择性间隙连接阻滞剂和选择性脂肪量和肥胖相关 (FTO) 酶抑制剂。甲氯芬那酸具有抗炎活性。

Meclofenamic acid is a non-selective gap-junction blocker and a selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic acid has anti-inflammatory activities.

Meclofenamic acid (0-100 μM, 24 h) inhibits FTO demethylation in a dose-response manner.Meclofenamic acid inhibits enzyme cyclooxygenase, with an IC50 about 1 μM, thereby inhibiting the production of prostaglandins.Meclofenamic acid inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins. Western Blot Analysis Cell Line:HeLa cells Concentration:0, 12.5, 25, 50, 100 μM Incubation Time:24 h Result:Inhibited FTO demethylation in a dose-response manner, and elevates the levels of cellular m6A in mRNA by targeting FTO.

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Meclofenamate

Others

Other Targets

Major prion protein

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644-62-2

296.15

C14H11Cl2NO2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (337.67 mM)

Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl

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(-20℃)

With Ice Pack

≥ 2 years